Genetics, atopy asthma

University of Groningen Genetics of asthma and atopy

Atopy is generally considered to be caused by interaction of genetic and environmental factors. Recently, an association of a C to T transition in the promoter region of the CD14 gene on chromosome 5q31.1 and atopic phenotypes was reported in a population study of school children in the United States. The aim of the present study was to investigate the association of the C allele of the CD14/-1...

Asthma and atopy

F emale sex hormones seem to have something to do with asthma and allergy. You might think this is a bit vague, but the research on this so far doesn’t merit anything stronger. Women of reproductive age are more likely to be admitted to hospital for asthma than men. Intrigued by this, people have studied the link between asthma or allergy and markers of female sex hormone levels—for example, ti...

Atopy and Asthma

Atopy is the genetic propensity to develop an immunoglobulin E antibody response to common allergens. The most common clinical manifestations of atopy are allergic rhinitis, asthma and atopic dermatitis. Asthma is a complex disorder of the airways, involving airway hyperresponsiveness, airflow obstruction that is at least partially reversible, and inflammation of the airways. Although atopy has...

Breastfeeding, atopy, and asthma.

Helicobacter, Hygiene, Atopy, and Asthma

The hygiene hypothesis links environmental and microbial exposures in early life to the prevalence of atopy, allergy, and asthma. Helicobacter pylori infection is typically acquired in childhood and acquisition of the infection is associated with poor household hygiene. Some population surveys have shown an inverse association between H. pylori infection and atopy, allergy, and asthma leading t...